The Unfinished Public Health Agenda of Chagas Disease in the Era of Globalization
Carlos Franco-Paredes1,2*, Maria Elena Bottazzi3,4, Peter J. Hotez3,4
1 Hospital Infantil de Mexico,
2 Department of Medicine,
3 Department of Microbiology, Immunology, and Tropical Medicine, The George Washington University, Washington, D.C., USA
4 Sabin Vaccine Institute, Washington, D.C., USA
PLoS Negl Trop Dis 3(7): e470. doi:10.1371/journal.pntd.0000470 - July 7, 2009
“….At the 100th anniversary of the discovery of Trypanosoma cruzi, much has been achieved but many challenges remain for the control and ultimate elimination of Chagas disease….”
Available online at: http://www.plosntds.org/article/info%3Adoi%2F10.1371%2Fjournal.pntd.0000470
“…..Many neglected tropical diseases (NTDs) began millions of years ago as enzoonotic diseases of wild animals that subsequently infected humans, leading in many cases to anthropozoonoses . Because of their impoverished circumstances, most humans infected with NTD agents have few choices but to face daily the intense selective pressures associated with high levels of exposure and transmission that often flourish in these impoverished settings . In this dynamic and relentless evolutionary battle, animal reservoirs, vectors, microbes causing NTDs, and humans are constantly adapting through what it is known as the “Red Queen Effect” from Lewis Carroll's Red Queen character ,. Typically, the battlegrounds of these molecular and ecological clashes are located in the poorest regions of developing countries where they mostly affect the world's most vulnerable populations ….”
Differential Regional Immune Response in Chagas Disease
Juliana de Meis and colleagues discuss the differential lymphocyte dynamics in distinct central and peripheral lymphoid organs following acute infection by Trypanosoma cruzi.
Feasibility, Drug Safety, and Effectiveness of Etiological Treatment Programs for Chagas Disease in
Oliver Yun and colleagues describe four diagnostic and therapeutic care programs for Chagas disease, and discuss the feasibility, safety, and effectiveness of treatment programs in resource-limited settings.
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