Thursday, September 3, 2009

[EQ] Global Burden of Diseases, Injuries and Risk Factors Study Operations Manual

Global Burden of Diseases, Injuries and Risk Factors Study Operations Manual


Final Draft - January 20, 2009

Harvard University; Institute for Health Metrics and Evaluation at the University of Washington; Johns Hopkins University;

University of Queensland; World Health Organization


The final draft of the Global Burden of Diseases, Injuries and Risk Factors Study Operations Manual is now available. It is intended to serve as a guide for the Expert Groups working on the GBD Study. There are opportunities to provide input and feedback, and instructions to do so are included in the operations manual.


Available online as PDF file [142p.] at:


“…..The GBD Study will focus on more than 220 diseases and injuries and more than 43 risk factors for 21 regions of the world. The GBD Study will not only serve to systematically incorporate the evidence on each major disease and risk factor into a coherent set of epidemiological estimates.


It will also provide an opportunity for concerted work on new age- and sex-specific mortality estimates, disability weight measurement, estimates of probabilities of disabling sequelae, standardization of tools and methods for resolving inconsistencies, dealing with missing data and quantifying uncertainty.


The GBD Study will conduct epidemiological reviews of all diseases, injuries, and risk factors; estimate mortality and causes of death for all countries in the world; derive new disability weights for an updated list of disabling sequelae, all leading to final, consistent and comprehensive estimates of the burden of diseases, injuries and risk factors for 1990 and 2005….”




Chapter 1: Introduction

Chapter 2: Participating Institutions

Chapter 3: Products and Deliverables

Chapter 4: Management Structure, Flow Diagrams, and Timeline

Chapter 5: Roles and Responsibilities

Chapter 6: Core Team Members

Chapter 7: External Advisory Board Members

Chapter 8: Analysis and Presentation of Regions

Chapter 9: Age Groups

Chapter 10: Mortality Envelopes (All-Cause Mortality)

Chapter 11: Causes of Death

Chapter 12: Concepts and Definitions for Quantifying Burden of Diseases, Injuries, and Risk Factors

Chapter 13: The GBD Study Cause Lists: Diseases and Injuries, Risk Factors, and Diseases as Risks

Chapter 14: Sequelae Definitions and Selection Criteria

Chapter 15: Disability Weights

Chapter 16: Years Lived with Disability (YLD) Estimation for Diseases and Injuries

Chapter 17: Using DisMod to Estimate Missing Epidemiological Parameters and Check Internal Consistency

Chapter 18: Comparative Risk Assessment and Diseases as Risk Factors

Chapter 19: Systematic Review

Chapter 20: Dealing with Bias and Missing Data

Chapter 21: Describing and Analyzing Uncertainty

Chapter 22: Publication Peer Review Process and Principles



If you have questions or comments about this or other aspects of the GBD Study, contact Rebecca Cooley, Project Officer at the Institute for Health Metrics and Evaluation at the University of Washington:



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