Survival and mortality of people infected with HIV in low and middle income countries:
results from the extended ALPHA network
AIDS:Volume 21 Suppl 6 November 2007p S1-S4
Ghys, Peter Da; Żaba, Basiab,c; Prins, Mariad,e
From the aJoint United Nations Programme on AIDS, Geneva, Switzerland
bLondon School of Hygiene and Tropical Medicine, London, UK
cNational Institute for Medical Research, Mwanza, Tanzania
dPublic Health Service, Amsterdam, the Netherlands
eAcademic Medical Center (CINIMA), Amsterdam, the Netherlands.
The Entebbe workshop on analysis of survival post-infection
“…..Published at a time when antiretroviral treatment (ART) is rapidly being scaled up in most low and middle income countries [2], this collection of papers represents a major collaborative effort to quantify and analyse the survival from HIV seroconversion to death in the absence of ART. The advent of effective treatment means it will not be possible to conduct any further studies of this nature in the future, so the results from these analyses together with a small number of previously published survival studies will serve as a baseline against which to assess the impact of ART in low and middle income countries. In addition, this new information is important for deriving parameters to model HIV epidemics.
Several papers examine the survival period from seroconversion to death, before ART became available in the study sites. Figure 1 shows the geographical spread of the study sites represented. Most of these studies were conducted in Africa, including three community-based studies in Kisesa, Tanzania [3], Rakai, Uganda [4], and Masaka, Uganda [5], and one among pregnant women recruited at an antenatal clinic in Kigali, Rwanda [6]. Two studies were conducted in Thailand, one among military recruits [7] and one among blood donors and their partners [8].
| | | November 2007, Volume 21 Suppl 6 | | | | |
Article/Title
| Format | | |
Survival and mortality of people infected with HIV in low and middle income countries: results from the extended ALPHA network.
Peter D Ghys; Basia {aba; Maria Prins | | | | Survival after HIV infection in the pre-antiretroviral therapy era in a rural Tanzanian cohort. Raphael Isingo; Basia {aba; Milly Marston; Milalu Ndege; Julius Mngara; Wambura Mwita; Alison Wringe; David Beckles; John Changalucha; Mark Urassa | | | | Survival of HIV-infected treatment-naive individuals with documented dates of seroconversion in Rakai, Uganda
Tom Lutalo; Ronald H Gray; Maria Wawer; Nelson Sewankambo; David Serwadda; Oliver Laeyendecker; Noah Kiwanuka; Fred Nalugoda; Godfrey Kigozi; Anthony Ndyanabo; John Baptist Bwanika; Steven J Reynolds; Tom Quinn; Pius Opendi
| | | | HIV-1 disease progression and mortality before the introduction of highly active antiretroviral therapy in rural Uganda. Lieve Van der Paal; Leigh Anne Shafer; Jim Todd; Billy N Mayanja; Jimmy AG Whitworth; Heiner Grosskurth | | | | HIV-infected Rwandan women have a high frequency of long-term survival. Philip J Peters; Etienne Karita; Kayitesi Kayitenkore; Jareen Meinzen-Derr; Dhong-Jin Kim; Amanda Tichacek; Susan A Allen | | | | The natural history of HIV-1 subtype E infection in young men in Thailand with up to 14 years of follow-up. Ram Rangsin; Phunlerd Piyaraj; Thira Sirisanthana; Narongrid Sirisopana; Onsri Short; Kenrad E Nelson | | | | Survival of blood donors and their spouses with HIV-1 subtype E (CRF01 A_E) infection in northern Thailand, 1992-2007. Kenrad E Nelson; Caroline Costello; Vinai Suriyanon; Supaluk Sennun; Ann Duerr | | | | Time from HIV seroconversion to death: a collaborative analysis of eight studies in six low and middle-income countries before highly active antiretroviral therapy. Jim Todd; Judith R Glynn; Milly Marston; Tom Lutalo; Sam Biraro; Wambura Mwita; Vinai Suriyanon; Ram Rangsin; Kenrad E Nelson; Pam Sonnenberg; Dan Fitzgerald; Etienne Karita; Basia {aba | | | | Estimating 'net' HIV-related mortality and the importance of background mortality rates. Milly Marston; Jim Todd; Judith R Glynn; Kenrad E Nelson; Ram Rangsin; Tom Lutalo; Mark Urassa; Sam Biraro; Lieve Van der Paal; Pam Sonnenberg; Basia {aba | | | | Mortality levels and trends by HIV serostatus in rural South Africa. Makandwe Nyirenda; Victoria Hosegood; Till Bärnighausen; Marie-Louise Newell | | | | Changing patterns of adult mortality as the HIV epidemic matures in Manicaland, eastern Zimbabwe. Jennifer Smith; Phyllis Mushati; Felicia Kurwa; Peter Mason; Simon Gregson; Benjamin Lopman | | | | Age-specific mortality patterns in HIV-infected individuals:
a comparative analysis of African community study data. Basia {aba; Milly Marston; Amelia C Crampin; Raphael Isingo; Sam Biraro; Till Bärnighausen; Ben Lopman; Tom Lutalo; Judith R Glynn; Jim Todd | | | | Cause of death and presence of respiratory disease at autopsy in an HIV-1 seroconversion cohort of southern African gold miners. Jill Murray; Pam Sonnenberg; Gill Nelson; Andre Bester; Stuart Shearer; Judith R Glynn | | | | Estimating the need for antiretroviral treatment and an assessment of a simplified HIV/AIDS case definition in rural Malawi. Nuala McGrath; Katharina Kranzer; Jacqueline Saul; Amelia C Crampin; Simon Malema; Lackson Kachiwanda; Basia {aba; Andreas Jahn; Paul EM Fine; Judith R Glynn | | | | | | | | | |
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