Defining Comorbidity:
Implications for Understanding Health and Health Services
Jose M. Valderas1, Barbara Starfield2, Bonnie Sibbald,1; Chris
1National Institute for
2Department of Health Policy and Management, Johns Hopkins Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD
3National Institute for
Annals of Family Medicine ✦ www.annfammed.org ✦ vol. 7, no. 4 ✦ July/August 2009
Available online at: http://www.annfammed.org/cgi/reprint/7/4/357
"……Comorbidity is associated with worse health outcomes, more complex clinical management, and increased health care costs. There is no agreement, however, on the meaning of the term, and related constructs, such as multimorbidity, morbidity burden, and patient complexity, are not well conceptualized.
In this article, we review definitions of comorbidity and their relationship to related constructs. We show that the value of a given construct lies in its ability to explain a particular phenomenon of interest within the domains of:
(1) clinical care,
(2) epidemiology, or
(3) health services planning and financing.
Mechanisms that may underlie the coexistence of 2 or more conditions in a patient (direct causation, associated risk factors, heterogeneity, independence) are examined, and the implications for clinical care considered. We conclude that the more precise use of constructs, as proposed in this article, would lead to improved research into the phenomenon of ill health in clinical care, epidemiology, and health services….."
"….We have defined the various constructs underpinning the co-occurrence of distinct diseases (comorbidity of an index disease, multimorbidity, morbidity
burden, and patient complexity), described how these are interrelated, and shown how different constructs might best be applied to 3 different research areas (clinical care, epidemiology, health services)………."
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