[EQ] Outlook: Chagas Disease

Outlook: Chagas Disease

Nature - Vol. 465, No. 7301 suppl. ppS3-S22 (24 June 2010) - DOI:doi:10.1038/465S3a

Website: http://www.nature.com/nature/outlook/chagas/index.html

“…..Chagas disease is one of the most neglected of the tropical diseases, yet millions of people are infected with it. There are only two available drugs to treat it, both of which are more than 40 years old and neither of which is ideal.

As the global population has become more internationally mobile, Chagas disease has spread from Latin America to become a worldwide threat.

This Outlook highlights some of the progress in understanding and treating Chagas disease over its 101 years of recent history and outlines the challenges still to be met….”

Outlook Editorial

Chagas disease — Michelle Grayson

Nature 465, S3 (24 June 2010) doi:10.1038/465S3a Full Text | PDF

“….Chagas disease is arguably the archetypal neglected disease. Millions of people — the vast majority in Latin America — are infected, yet it is seldom discussed. It has struggled to achieve even a fraction of the notoriety of other neglected diseases, such as malaria. Its prevalence in immigrants to Spain, Portugal, the United States and other parts of the world has gone largely unnoticed. Even those who live in endemic areas are rarely aware of it…”

Feature

Chagas disease 101 — Julie Clayton

Nature 465, S4—S5 (24 June 2010) doi:10.1038/nature09220 Full Text | PDF

‘…It is 101 years since Carlos Chagas discovered the parasite responsible for the disease that now bears his name. What progress has been made since this discovery? Here Julie Clayton gives the low-down on Chagas disease…”

Opinion

Chagas disease: a new worldwide challenge — José Rodrigues Coura & Pedro Albajar Viñas

Nature 465, S6—S7 (24 June 2010) doi:10.1038/nature09221

Full Text | PDF

 

Feature

Who, how, what and where? — Nature 465, S8—S9 (24 June 2010) doi:10.1038/nature09222

Full Text | PDF

 

Feature

Country by country — Anna Petherick

Nature 465, S10—S11 (24 June 2010) doi:10.1038/nature09223

Full Text | PDF

 

Feature

Chagas disease: pushing through the pipeline — Julie Clayton

Nature 465, S12—S15 (24 June 2010) doi:10.1038/nature09224

Full Text | PDF

 

Feature

The promise of T. cruzi genomics — Julie Clayton

Nature 465, S16—S17 (24 June 2010) doi:10.1038/nature09225

Full Text | PDF

 

Feature

Chagas disease in the Chaco — Anna Petherick

Nature 465, S18—S20 (24 June 2010) doi:10.1038/nature09226

Full Text | PDF

 

Feature

Campaigning for Chagas disease — Anna Petherick

Nature 465, S21—S22 (24 June 2010) doi:10.1038/nature09227

Full Text | PDF

 

News and Views

Parasitology: Triple genome triumph —  Declan Butler

Nature 436, 337—337 (21 July 2005) doi:10.1038/436337b

Full Text | PDF

 

Commentary Immunology south of the equator in the Americas —

Gabriel A. Rabinovich, Alexis M. Kalergis, Norberto W. Zwirner & Wilson Savino

Nature Immunology 9, 1087—1090 (2008) doi:10.1038/ni1008-1087

Abstract | Full Text | PDF

 

Perspective

Trypanosoma cruzi surface mucins: host-dependent coat diversity —

Carlos A. Buscaglia, Vanina A. Campo, Alberto C. C. Frasch & Javier M. Di Noia

Nature Reviews Microbiology 4, 229—236 (March 2006) doi:10.1038/nrmicro1351

Abstract | Full Text | PDF

 

Article

Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease —

Juan M. Bustamante, Lisa M. Bixby & Rick L. Tarleton

Nature Medicine 14, 542—550 (20 April 2008) doi:10.1038/nm1744

Abstract | Full Text | PDF

 

Perspective

The Trypanosoma cruzi-host-cell interplay: location, invasion, retention — Luciana O. Andrade & Norma W. Andrews

Nature Reviews Microbiology 3, 819—823 (9 September 2005) doi:10.1038/nrmicro1249

Abstract | Full Text | PDF

 

 

 

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